Fig. 3

Enrichment of known and de novo sequence motifs in the eCLIP data of individual RBPs. a Enrichment scores computed by comparing the frequency of known motifs among the top CLIP peaks identified by the indicated method with the frequency in background regions (random subsets of regions that were least enriched in CLIP reads, see “Methods”). Each peak finder is shown in a different color. The enrichments of the de novo motifs are indicated by stars, red for RCRUNCH peak center, and blue for RCRUNCH crosslink. b The known RBP-specific motifs from ATtRACT [23] that were used in the analysis. c Most significantly enriched de novo motif predicted by Phylogibbs [37] in the “RCRUNCH peak center” sites from each sample. d Most significantly enriched de novo motif predicted by Phylogibbs in the “RCRUNCH crosslink” sites from each sample