Fig. 4

NSD2 knockdown leads to cell-type specific alterations in chromatin accessibility. a Volcano plots demonstrating differentially accessible regions from NSD2 Low to NSD2 High per cell line (abs(L2FC) > 1, FDR < .01). b Bar plot showing distribution of annotated ATAC-seq peaks for each NSD2-Low and NSD2-High cell line. c Correlation boxplots of chromatin accessibility changes and compartment switches (AB, BA, stable) for each cell line. d Association barplots showing fraction of ATAC-seq peaks (increased, decreased, stable) at compartment switches (AB, BA, stable). e Enrichment analysis using LOLA for increased ATAC-seq peaks concordant with increased gene expression and B to A compartment switches and shifts (left) and decreased ATAC-seq peaks concordant with decreased gene expression and A to B compartment switches and shifts (right)