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Fig. 2 | Genome Biology

Fig. 2

From: NSD2 E1099K drives relapse in pediatric acute lymphoblastic leukemia by disrupting 3D chromatin organization

Fig. 2

NSD2 EK-related B to A compartment switches correlate with gene expression changes. a PCA representation of triplicate RNA-seq data showing top 1000 genes. b Volcano plots demonstrating differentially expressed genes (abs(L2FC) > 0.32, p-value < 0.05) per cell line from NSD2 Low to NSD2 High with top 10 labeled. c Correlation boxplots of gene expression changes and compartment switch status (AB, BA, stable) for each cell line. d Association barplots showing fraction of genes (increased, decreased, stable) at compartment switches (AB, BA, stable)

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Genome Biology

ISSN: 1474-760X

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