Fig. 5
From: Genetic mapping and molecular mechanism behind color variation in the Asian vine snake
SMARCE1 deficiency in Caco2 cells blocks recruitment of tfec in nucleus. AÂ SMARCE1 expression in purified Caco2 cell population determined by qRT-PCR. Ctl, control group; siRNA, siRNA-injected group. B Immunoblotting analysis of SMARCE1 in Caco2 cells. Ctl, control group; siRNA1 and siRNA2, siRNA-injected groups. CÂ SMARCE1 and Foxd3 expression in purified Caco2 cell population determined by qRT-PCR. Ctl, control group; siRNA1 and siRNA2, siRNA-injected groups. D Immunofluorescence staining of SMARCE1 and tfec showing substantial accumulation of tfec fluorescence signals around the nucleus in SMARCE1-deficient Caco2 cells. E Schematic of possible mechanism by which defective SMARCE1 impedes tfec nuclear recruitment