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Table 2 RNA-seq results for TF knockdown experiments in K562. For each TF, we provide the number of statistically significant IR events that are up-regulated (down-regulated), i.e., exhibit increased (decreased) retention with respect to the wild-type. Within the up-regulated events we provide the number of events with occurrences of the motif compared to the background set composed of IR events. This is done in both the intron and the flanking exons. The significance of the difference in the rates of occurrence of the motif is provided in the last column. In all cases the significance was exhibited in the flanking exons, except for E2F4 which exhibited similar levels of significance in both the introns and flanking exons

From: Evidence for the role of transcription factors in the co-transcriptional regulation of intron retention

TF

Up-regulated

Down-regulated

Motif occurrences

p-value

   

Intron

Exon

 

MAZ

69

34

23% (25%)

31% (16%)

0.001

SP1

86

18

69% (64%)

86% (51%)

1.3E−9

SP2

99

25

31% (27%)

41% (16%)

1.4E−9

E2F4

174

58

18% (12%)

18% (11%)

0.008