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Fig. 5 | Genome Biology

Fig. 5

From: Widespread allele-specific topological domains in the human genome are not confined to imprinted gene clusters

Fig. 5

The Bitter Taste Receptor (TAS2R) cluster on Chromosome 12p13.2 is within an ASTAD. a Contact matrices for diploid, haplotype phased alleles and their subtraction matrices at 10kb resolution in GM12878, IMR-90, and H1-hESC. Arrows below the CTCF track indicate boundaries of the ~800kb TAD which hosts the ASTAD (as a subTAD). ASTAD shown as triangles. The ASTAD is identified in GM12878 (chr12:10,915,000–11,405,000, Z-score = 4.06) and IMR-90 (chr12:10,900,000–11,370,000, Z-score = 4.20) with >90% overlap. H1-hESC was not called as an ASTAD (Z-score = 1.56). Cscores below the contact matrices show clear allelic differences that varied between cell lines. b Quantitative RT-PCR analysis of RNA transcript levels for TAS2Rs genes and the lncRNA PRH1-PRR4

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Genome Biology

ISSN: 1474-760X

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