Fig. 5
From: DNA methylation entropy as a measure of stem cell replication and aging
Change in entropy in different tissues. a Average Jensen-Shannon sistances for each locus (JSD) in young (4 months) and old (24 months) mice in the colon (COL) in both stem (Lgr5 − GFP +) and nonstem (Lgr5 − GFP −) cells (fold change calculation in the “Methods” section). b Same as a for the given tissue. c Scatterplot of fold change in JSD with age on the x-axis vs 30-day tissue renewal rate on the y-axis: COL + = colon stem cells, COL − = colon nonstem cells, SI + = small intestine (USI + LSI) stem cells, SI − = small intestine (USI + LSI) nonstem cells. d UpSet plots of commonly detected loci with Jensen-Shannon distance (JSD) > 0.2 in different organs (liver, lung, muscle, spleen, blood, kidney, heart, and intestines)