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Table 1 Selected loci for binary and quantitative traits. The number of significant genes per locus for GeneScan3D, BIGKnock, and BIGKnock significant genes are shown. The putative causal gene is shown in boldface font

From: BIGKnock: fine-mapping gene-based associations via knockoff analysis of biobank-scale data

BIGKnock locus-trait

position (hg19)

# GeneScan3D

# BIGKnock

BIGKnock genes

BRAP-CAD

12: 111,986,818–112,986,818

12

3

ALDH2, ATXN2, BRAP

UBE2Z-Asthma

17: 46,948,346–47,948,346

11

2

NGFR, UBE2Z

AGPAT1-T2D

6: 32,126,272–33,126,272

12

1

AGPAT1

CPEB3-T2D

10: 93,966,910–94,966,910

6

2

MARCHF5, CPEB3

IL2RA-Hypothyroidism

10: 5,606,266–6,606,266

8

2

GDI2, IL2RA

CD69-Hypothyroidism

12: 94,22,652–10,422,652

7

2

CD69, CLEC2B

HMGCR-Hyperlipidemia

5: 74,105,220–75,105,220

7

1

HMGCR

BUD13-Hyperlipidemia

11: 116,148,917–117,148,917

12

3

APOA5, BUD13, ZNF259

ASGR1-Cholesterol

17: 6,569,412–7,569,412

43

2

ASGR1, CD68

SLC39A8-BP-Diastolic

4: 103,269,304–104,269,304

6

1

SLC39A8

DBH-BP-Diastolic

9: 135,649,709–136,649,709

6

3

ADAMTS13, DBH, SARDH

ANGPTL4-Cholesterol

19: 7,951,937–8,951,937

9

1

ANGPTL4

RAB11A-Neutrophil count

15: 65,544,465–66,544,465

8

1

RAB11A

ZHX3-Calcium

20: 39,455,078–40,455,078

6

1

ZHX3

PPARG-LDL cholesterol

3: 11,739,931–12,739,931

6

1

PPARG

POLDIP2-LDL cholesterol

17: 26,194,861–27,194,861

22

3

POLDIP2, SLC13A2, TMEM199

E2F4-RBC count

16: 66,229,250–67,229,250

18

3

E2F4, FAM96B, KIAA0895L

ENSA-WBC count

1: 150,095,537–151,095,537

26

2

ENSA, MCL1

E2F2-Lymphocyte count

1: 23,019,508–24,019,508

11

1

E2F2

KCTD17-Hematocrit percentage

22: 36,962,936–37,962,936

11

3

KCTD17, MPST, TMPRSS6

SAMD7-MCH

3: 169,029,895–170,029,895

10

3

ACTRT3, LRRC31, SAMD7

ITGA4-Monocyte percentage

2: 182,392,917–183,392,917

6

3

CERKL, ITGA4, NEUROD1