Fig. 3

Hybrid endothelial cell states in gastric cancer. A UMAP of 3684 endothelial cells color coded for tissue (left) and cluster annotation (right). B Log ratio of average fraction per endothelial cell cluster in tumor to normal tissue (n = 20) (top). Wilcoxon rank-sum test with holm correction, **: p < 0.01. Dotplot of top markers per cluster showing the scaled average expression and the percentage of expression (bottom). C Heatmap of differentially expressed genes between endothelial cells of non-malignant and malignant biopsies contained in indicated gene ontology terms. Shown is the scaled average expression and the percentage of expression. D, E Overall survival of gastric cancer patients in TCGA, groups split by SERPINE1 levels and top 20 marker genes of EN10 cluster, respectively.