Fig. 6
From: MoDLE: high-performance stochastic modeling of DNA loop extrusion interactions
Optimization of individual barriers and computation of barrier and LEF profiles. A Micro-C (hESC) data from a 5Mb region on chromosome 1 (20–25 Mbp). B MoDLE output for the same region, where individual barriers are optimized from Micro-C data. C MoDLE output for the same region using Rad21 ChIP-seq data as input, D Computed barrier occupancy profile from MoDLE trained on Micro-C data (normalized with PUU = 0.7). E Computed LEF occupancy profile from MoDLE trained on Micro-C data. F CTCF ChIP-seq data from the same region. G Rad21 ChIP-seq data from the same region