Fig. 1

Phylogenetic distribution and genomic characteristics of pseudogenes. a, b show the assignments of pseudogenes to the branches of phylogenetic tree of human and mouse, respectively. Scatter plot represents the relationship between evolution branch and the corresponding number of pseudogenes in this branch. The evolutionary time (myr) is defined as the middle point of each branch. c Sequence conservations of randomly shuffled intergenic regions, pseudogenes with different ages, CDS, and untranslated terminal regions. d Genomic profile of the chromosome q33.1 locus. The enlarged picture depicts a highly conserved exon from the pseudogene METTL21EP. The Multiz alignment of 28 vertebrate species, the per-base phastCons, and the phyloP conservation scores are presented. e Proportions of X-linked pseudogenes originating in each phylogenetic branch