Fig. 8
From: Deciphering the impact of genetic variation on human polyadenylation using APARENT2
MPRA validation in multiple cell lines. A APA reporter system for measuring variant effects in HEK293T, SK-N-SH and HMC3. B Predicted vs measured variant effects (LORs) in the three assayed cell lines. C Predicted vs measured effects of 9 GWAS SNPs (PIP = posterior inclusion probability). D Measured effects of 2 SNVs in the F2 and SCAF8 genes (orange), alongside common gnomAD SNPs (blue). E Measured effects of 76 autism variants from An et al. [51]. p-values are computed with two-sided Wilcoxon tests