Fig. 4
From: Deciphering the impact of genetic variation on human polyadenylation using APARENT2
Redundancy of functional hexamer motifs in human polyadenylation signals. A Position weight matrix (PWM) of the CSE motif, as measured in the MPRA of Bogard et al. [36]. B Predicted vs measured log odds ratio of CSE mutations from the MPRA (n = 628). Right: Log odds ratio predicted by APARENT2 vs the effect sizes predicted by a linear hexamer model trained on the same data. C Interpretation of a functionally silent CSE mutation in the TPMT gene. D Interpretation of a variant with dampened effect size in the SMAD4 gene. E Boxplot showing measured LORs of all assayed CSE mutations [36]. p-values are computed with two-sided t-tests