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Fig. 1 | Genome Biology

Fig. 1

From: Significant variation in the performance of DNA methylation predictors across data preprocessing and normalization strategies

Fig. 1

Schematic overview of the analysis plan to evaluate DNAm algorithm performance. DNAm analyses are conducted using DNAm EPIC array samples in JHS. JHS includes a significant number of technical replicate pairs thereby allowing for a careful investigation of how the removal of unwanted technical variation impacts DNAm algorithm performance across 101 data processing pipelines. JHS has also collected information on disease-related phenotypes, including mortality status after follow-up. This allowed us to assess how the removal of technical variation in DNAm predictor estimates by a data processing pipeline impacts downstream phenotypic association analyses

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Genome Biology

ISSN: 1474-760X

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