Fig. 5
From: Local CpG density affects the trajectory and variance of age-associated DNA methylation changes
Many age-associated changes in DNA methylation are specific to older individuals. a CpG density associates with variation in age-associated methylation changes in a second independent cohort. Boxplot showing estimated rates of change in DNA methylation from the 406 individuals aged > 65 in Generation Scotland cohort set 1 plotted against CpG density ± 300 bp from the CpG. The Spearman correlation, Rho, and p-value, T-test, for the association are given. For plotting, CpG density is binned into equally sized groups. Lines = median; Box = 25th–75th percentile; whiskers = 1.5 × interquartile range from box. b CpG density associates with changes in DNA methylation in younger individuals. Boxplot showing estimated rates of change in DNA methylation from the 4695 individuals aged ≤ 65 in Generation Scotland cohort set 1 plotted against CpG density ± 300 bp from the CpG. The Spearman correlation, Rho, and p-value, T-test, for the association are given. For plotting, CpG density is binned into equally sized groups. Lines = median; Box = 25th–75th percentile; whiskers = 1.5 × interquartile range from box