Fig. 2

Epigenetic and chromatin interactions near the candidate GSH sites in blood and brain. a Genome browser screenshot of a representative GSH in blood. From top to bottom: Interaction heatmap and TADs from Hi-C in GM12878 cells. Chromatin interaction loops from promoter capture Hi-C in blood cells (see Method section for details). The coordinate of the GSH. Active and repressive genomic regions defined by 15-state ChromHMM from blood cells in the Roadmap project (Additional file 9: Table S8), and reference genes. b Genome browser screenshot of a representative GSH in brain. From top to bottom: Interaction heatmap and TADs from Hi-C in brain hippocampus. Chromatin interaction loops from promoter capture Hi-C in brain cells (dorsolateral prefrontal cortex, hippocampus, and neural progenitor cells). The coordinate of the GSH. Active and repressive genomic regions defined by 15-state ChromHMM from brain cells in the Roadmap project (Additional file 9: Table S8), and reference genes. Regions surrounding the GSH sites are highlighted with blue shade