Fig. 1
From: Rapid divergence of a gamete recognition gene promoted macroevolution of Eutheria
Two-dimensional comparison of mouse, opossum, and platypus genomic loci spanning AchE-Tfr2.A Comparison of syntenic loci from mouse Chr 5 (~310 kb) encompassing 12 identified genes and opossum Chr 2 (~340 kb) encompassing 11 of the same 12 genes. The arrows represent the locations and orientations of the respective genes (first through last exons plus introns; blue arrow = mouse Zan). Note the co-linearity and conserved order and orientation of genes 1–5 (AchE–Ephb4) and 7–12 (Epo–Tfr2), and the generally greater content of intergenic and intronic DNA in the opossum. Note also the comparatively short segment of intergenic DNA (30 kb) between opossum Ephb4 and Epo, and the corresponding discontinuity in the co-linear relationship (dotted lines) between the mouse and opossum loci, reflecting the absence of ~100 kb Zan in the opossum. B Corresponding comparison of the mouse Zan locus with the syntenic locus from platypus Chr X5 (~270 kb). Note the presence of a Zan-like gene (ZanL) in platypus between Ephb4 and Epo