Fig. 6
From: Dissection of multiple sclerosis genetics identifies B and CD4+ T cells as driver cell subsets
A Venn diagram of the putative causal CD4 T and B cell genes. B Heatmap of canonical pathway enrichment for the putative causal genes in CD4 T cells, B cells, common in CD4 T and B cells, unique in CD4 T cells, and unique in B cells. Only pathways with FDR<5% in at least one gene list are displayed (n = 1950). The grayscale depicts level of statistical significance. C Scatterplot of −log10(FDR) of canonical pathway enrichment for putative causal genes unique in CD4 T cells (X-axis) vs. B cells (Y-axis). The dashed red lines indicated FDR<5%. The size of the dots depicts the total number of genes in the respective pathway