Fig. 4

Landscapes of distal interactions in the reconstructed cell networks. A–D Evaluation of the over- or under-representation of particular types of distal interactions in the reconstructed cell interaction networks with the 4 datasets. The results are represented as dot heatmaps showing the enrichment or depletion of the distal interactions between certain cell types. The color of the dots represents significance (−log₁₀P) determined by comparing with the permutation test, in which positive values indicate enrichment, and negative values indicate depletion. E–G Examples of distal interactions between a glutamatergic neuron and GABAergic neurons (E), between an epithelial cell and stromal cells (F), and between a T cell and other T cells (G). The proximal interactions between neighboring cells are shown as backgrounds