Fig. 8

eQTL analysis results. A Manhattan plot reporting only the 5 best p-values per transcript. For visual comfort, the p-value threshold (dashed line) was set to 1e−6. B Zoomed-in slice of the Manhattan plot, showing all p-values in the genomic window chr18:0-1200000. Transcripts associated with at least 1 p-value lower than 10e−6 are highlighted in color, with all SNPs associated shown in the same color. The width of the colored bands corresponds to the full length of the transcript. C Normalized TPM expression of MIKK lines for 3 significant eQTL SNPs associated with transcript ENSORLT00000002786.2 (cyp17a2 gene). Lines are sorted according to their genotypes (AA, AB, or BB). Each point represents one individual line, overlaid with letter-value plot boxes showing the quantile distribution [59]. D Metagene density plot with upstream and downstream 500k regions showing the density of significant eQTL hits according to their positions relative to a prototypic gene. Values are aggregated in 100 bins of 5000 bases for the adjacent regions and 50 bins dynamically computed for p-values falling inside gene bodies. Densities are weighted by bin length to allow comparisons across the different regions