Fig. 2
From: Comparison of confound adjustment methods in the construction of gene co-expression networks
Comparison of covariate adjustment methods. A Area under the curve (AUROC) scores for performance evaluation of each adjustment method. B Proportion of edges in each global co-expression network that represent TF-target gene interactions from the DoRothEA gene set resource. C Aucodds scores for performance evaluation of each adjustment method per module detection method. Each histogram shows the distribution of aucodds score rankings by each cut-off-tissue combination (1 = best-performing method, highest aucodds score), with dashed lines marking the mean rank. D Summary of performance evaluation results. Heatmap colors reflect the average score of a performance measure across tissues (scaled from 0 to 1). Module comparison to Marbach et al. resource [16] shows average aucodds score rankings (C). The average scores for each evaluation measure are provided in their respective cellsÂ