Fig. 3
From: IDEAS: individual level differential expression analysis for single-cell RNA-seq data
A Distribution of cell-level read-depth, with median around 10,000 and range from 2,414 to 105,488. B Correlation between the -log10(p-values) of DE testing between the two approaches to estimating individual-specific distribution: ZINB or empirical CDF. The genes were divided into 5 groups based on the proportion of cells where the observed gene expression is 0. C The P-value distribution when estimating individual-specific distribution using ZINB, followed by a distance calculation using the Wasserstein distance and a p-value calculation using permutation. D Same as C except that the input data are not the observed counts but the counts sampled from the cell specific ZINB estimated by DCA [16]