Fig. 1
From: IDEAS: individual level differential expression analysis for single-cell RNA-seq data
An overview of the IDEAS pipeline. Here,we illustrate a toy example with 2 cases and 3 controls, with 2 or 3 cells per individual. For each gene, we summarize its gene expression distribution within each individual (e.g., P(x) and Q(x) in the figure) and then calculate the distance of such distributions between any two individuals and obtain a distance matrix (the bottom right corner of the figure). This distance matrix, combined with additional individual-level covariates, is used for differential expression analysis between cases and controls