Fig. 5

Functionality of statistically significant loops. A Activation rate of ChIA-PET analytical methods across all ChIA-PET testing datasets. B Activation rate of HiChIP analytical methods across all HiChIP testing datasets. C Overlap between ChIA-PET K562-H3K27ac loops and CRISPR/Cas9 verified loops. D Overlap between HiChIP K562-H3K27ac loops and CRISPR/Cas9 verified loops. E Example of enhancer-MYC interactions from K562-H3K27ac ChIA-PET datasets. F Example of enhancer-SEMA7A interactions from K562-H3K27ac HiChIP datasets. CID + MICC, indicates the combination of CID loop calling and significance detection with the MICC package. The gray square indicates that the corresponding method failed to detect loops. The dark squares indicate that the scaled accuracy was larger than 0.95