Fig. 1

An epigenetic score for cognitive ability associates with measured cognitive ability, health and lifestyle factors and neuro-inflammatory protein levels. Variance explained for general cognitive ability (g) by a cognitive Epigenetic Score (EpiScore; green), polygenic score (purple) and in combination (orange) (A). Age- and sex-adjusted associations between risk factors for cognitive decline and dementia and the EpiScore (red) and measured g (turquoise) with 95% confidence intervals—deprivation and 6-m walk have been reverse coded such that higher values correspond to less deprivation and faster walking speed (B). Comparison of age- and sex-adjusted associations between the EpiScore and measured g score with 70 inflammation-related (C) and 90 neurology-related (D) proteins. Coloured points in C and D are significant after Bonferroni-correction: orange—common to both, pink—unique to EpiScore, blue—unique to measured g; dashed lines show perfect correlation (y=x)—the grey lines show the linear regression slope with 95% confidence interval