Fig. 2
From: Universal annotation of the human genome through integration of over a thousand epigenomic datasets
Full-stack state emission parameters. A Each of the 100 rows in the heatmap corresponds to a full-stack state. Each of the 1032 columns corresponds to one dataset. For each state and each dataset, the heatmap gives the probability within the state of observing a binary present call for the dataset’s signal. Above the heatmap, there are two rows, one indicating the cell or tissue type of the dataset and the other indicating the chromatin mark. The corresponding color legends are shown towards the bottom. The states are displayed in 16 groups with white space between each group. The states were grouped based on biological interpretations indicated by the color legend at the bottom, with group abbreviations defined in the main text. Full characterization of states is available in Additional Files 2-6. The model’s transition parameters between states can be found in Additional File 1: Fig. S6. Columns are ordered such that datasets profiling the same chromatin marks are next to each other. B Each row corresponds to a full-stack state as ordered in A. The columns correspond to the top 10 datasets with the highest emission value for each state, in order of decreasing ranks, colored by their associated chromatin marks as in A. C Similar to B, but datasets are colored by the associated cell or tissue type group. On right, the cell or tissue groups primarily associated with some of the enhancer states are noted