Fig. 4
Most cancer types display a positive correlation between mtOXPHOS and nuOXPHOS expression. A Heatmap showing median Spearman’s ρ for mtOXPHOS and nuOXPHOS gene expression using MRN normalisation in 31 TCGA cancer types combined (50 samples from each tissue, sampled 100 times). B Boxplot showing median Spearman’s ρ for 100 iterations of mtOXPHOS genes with random nuclear genes or mtOXPHOS with nuOXPHOS genes for 31 TCGA cancer types combined. C Observed median Spearman’s ρ between mtOXPHOS and nuOXPHOS genes for 31 TCGA cancer types. Error bars show bootstrap 95% confidence interval. The blue bar indicates observed correlation significantly lower 0 (bootstrap empirical p value, FDR-adjusted < 0.05), red bars indicate observed correlation significantly higher than 0 and grey bars indicate FDR > 0.05. Z statistics and p values for observed value vs mtOXPHOS-random nuclear correlations are shown in Additional File 1: Table S2. D Median mtOXPHOS-nuOXPHOS ρ within matched samples of tumour (purple) or normal tissue (green) from TCGA projects. Error bars show bootstrapped standard error. E mtOXPHOS-nuOXPHOS correlation heatmaps for thyroid cancer (TCGA) matched normal tissue samples (above) and tumour samples (below). Abbreviations for cancer types are given in Additional File 1: Table S5