Fig. 2

Analysis of tissue-specific exons. A Heatmap and hierarchical clustering of standardized PSI values obtained from VastDB. The heatmap only shows events with a standard deviation of PSI values ≥ 20. The heatmap shows that clusters of exons upregulated in neural tissues and muscle/heart tissues are dominant (clusters C1 and C3). B NEASE analysis shows that 28% and 27% for both neural and muscle upregulated exons, respectively, are encoding protein features: domains, linear motifs, and residues. For these subgroups of events, the exact protein complexes involved can be identified, and NEASE enrichment can be performed. C, D Comparison between gene-level enrichment and NEASE enrichment for the two sets of exons