Fig. 7

Identifying reads containing human long interspersed repeat elements. a Diagram of experimental strategy for enriching human mobile elements, including interspersed repeats. A guide RNA specific to each repeat class directs Cas9 to cut the DNA and ligate a sequencing adapter. However, adapters are also ligated to some sequences without repeat elements. Subsequent nanopore sequencing produces both target and non-target reads. b Pie charts of the proportion of L1Hs repeat elements from Cas9 enrichment only vs. SquiggleNet classification. c Classification metrics demonstrating SquiggleNet’s ability to distinguish reads with or without L1Hs repeats