Fig. 1

Read-until pipeline overview. a A DNA molecule translocates through a nanopore, generating electric signals (squiggles). SquiggleNet rapidly classifies the molecule to determine whether it is a sequence of interest. If the molecule is accepted by the classifier, it is sequenced to full length. Otherwise, the molecule is ejected from the pore, freeing the pore to sequence another molecule. b SquiggleNet employs 1D-ResNet-styled bottleneck blocks with increasing numbers of filters. Average pooling and a final fully connected layer are performed after the last convolutional block