Fig. 3

Motif enrichment analysis reveals alx transcription factor family as putative regulator of iridophore development. a, b Heatmaps representing motif enrichment, gene expression, and gene fold change of transcription factors when comparing late NCC differentiation into melanophores (a) and iridophores (b). c Bar plots representing frequency and distribution of iridophore-associated DM/ARs with a particular TF motif. d Heatmaps representing DNA methylation and ATAC signal across iridophore-associated DM/ARs with specific TF motifs. e ATAC-seq footprint signatures of alx transcription factor candidates. f Model of guanine synthesis cycle. Iridophore-specific DEGs are shown in bold. Boxes above DEGs are color-coded based on detection of CREs containing TF motifs within 50 kb of DEG promoters