Fig. 6

Integrative analyses of TCGA data reveal clinically relevant unitary pseudogenes in human cancer. A The unitary pseudogenes with significant up-/downregulation in tumors vs. the corresponding normal tissues in at least four cancer types, based on TCGA data are shown. The circle size is proportional to the significance level and the log₂(Fold-Change) between tumors and normal tissues is shown by color scale. The unitary pseudogenes, whose expression was significantly B associated with patient OS in at least three cancer types or C associated with patient RFS in at least two cancer types are shown. The circle size is proportional to the significance level. The unitary pseudogenes, whose expression showed positive and negative natural logarithm of hazard ratio (HR) in a given cancer type, is colored in red and blue, respectively. D Higher CMAHP expression was associated with better patient OS in LUAD and SKCM, respectively. E Higher expression of unitary pseudogene CPHL1P was associated with worse patient OS in KIRC and worse patient RFS in PRAD, respectively. F Higher MYH16 expression was associated with both worse patient OS and RFS in PAAD. The p values shown in the figures were calculated based on log-rank test. The Kaplan-Meier survival curves are plotted as solid lines accompanied by 95% confidence interval