Fig. 2
From: Deterministic transition of enterotypes shapes the infant gut microbiome at an early age
Species-level prevalence and strain-level association pattern of enterotypes. A Temporal distribution of the top 24 most dominant species among four enterotypes (n = 1165). The size of each circle is proportional to the relative abundance of each species. Only the species with relative abundance > 0.2 are shown. B The relative abundance of Bacteroides spp. and Bifidobacterium spp. varies over time. The shaded regions indicate the 95% confidence intervals for the fit of the lines. C–E Phylogenetic trees of different strains of Bifidobacterium longum denoted with developmental stages (C), enterotypes (D), and countries (E), respectively. Each node in the phylogenetic tree represents a specific strain from one infant. F Strain-level association between enterotypes and developmental stages in the top ten most dominant species. The height of each peak and bar indicates the number of strains enriched in this enterotype. Red asterisk on the right indicates a significant correlation (chi-square test, P < 0.001) between enterotypes and developmental stages. G Aggregation index (AI) quantifying the clustering closeness in the phylogenetic trees of top 10 species, where a higher AI value indicates a closer phylogenetic relationship among the strains in the same group (enterotype or country). H Pie diagrams of different enterotypes or countries in the top five subclades of representative species