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Table 4 List of all loci with significantly changed chromatin interactions after TNF stimulation and expression of associated genes after TNF stimulation

From: Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability

Locus

Interacting gene

Base mean expression

log2Fold Change

lfcSE

stat

p value

padj

12

SPRED2

772.22

− 0.34

0.08

− 4.36

1.29E−05

7.23E−05

19

SLC4A7

3702.62

− 0.23

0.13

− 1.80

0.072

0.145

20

PXK

1012.38

− 0.33

0.11

− 3.05

0.002

0.008

23

RBPJ

5319.00

− 0.56

0.22

− 2.51

0.012

0.032

24

IL6ST

18,850.31

0.72

0.08

8.91

4.91E−19

2.30E−17

30

TNFAIP3

7841.42

4.57

0.19

23.43

2.14E−121

3.51E−118

34

CDK6

4906.40

0.92

0.12

7.89

3.05E−15

9.21E−14

35

TNPO3

1671.71

0.05

0.07

0.76

0.449

0.597

41

PHF19

1065.75

0.71

0.14

5.09

3.56E−07

2.74E−06

42

TRAF1

1041.51

2.80

0.22

12.65

1.14E−36

1.98E−34

48

VPS37C

552.68

0.71

0.07

10.56

4.76E−26

3.90E−24

52

CDK2

648.74

0.85

0.13

6.69

2.23E−11

3.72E−10

52

RAB5B

1805.92

− 0.24

0.06

− 4.06

4.88E−05

2.42E−04

52

RNF41

1878.98

− 0.63

0.11

− 5.62

1.93E−08

1.88E−07

52

ANKRD52

1954.38

0.23

0.07

3.09

0.002

0.007

52

CNPY2

1033.14

0.37

0.07

5.30

1.16E−07

9.89E−07

52

PAN2

312.46

− 0.23

0.08

− 2.80

0.005

0.015

52

STAT2

4951.27

0.74

0.20

3.77

1.64E−04

7.21E−04

52

TIMELESS

728.81

1.11

0.14

8.10

5.66E−16

1.87E−14

52

GLS2

18.80

0.34

0.26

1.31

0.191

0.317

53

SLC26A10

10.97

− 0.29

0.39

− 0.75

0.455

0.603

53

OS9

5461.71

− 0.12

0.07

− 1.83

0.068

0.138

53

AGAP2

5.83

0.43

0.31

1.36

0.173

0.294

53

TSPAN31

370.51

− 0.29

0.11

− 2.56

0.010

0.028

53

CDK4

1630.73

0.06

0.07

0.88

0.378

0.529

53

AVIL

64.47

− 0.44

0.15

− 2.93

0.003

0.011

53

CTDSP2

3707.75

− 0.47

0.06

− 7.79

6.45E−15

1.85E−13

54

SH2B3

1493.15

0.52

0.10

5.29

1.25E−07

1.06E−06

54

ATXN2

781.23

− 0.05

0.08

− 0.71

0.478

0.625

64

ORMDL3

800.27

0.40

0.08

4.75

1.99E−06

1.32E−05

64

PSMD3

1842.20

0.18

0.05

3.66

2.53E−04

0.001

65;68

IFNAR2

644.38

2.81

0.11

26.14

1.14E−150

2.92E−147

68

IFNAR1

2355.18

0.95

0.08

12.55

3.95E−36

6.53E−34

68

IFNGR2

1248.98

1.10

0.08

12.90

4.71E−38

9.03E−36

68

ITSN1

1138.10

− 0.24

0.11

− 2.10

0.036

0.080

  1. Genes with a log2fold change > ± 0.5 and padj < 0.05 are marked in bold. lfcSE standard error for log2 fold change, stat statistic value for the null hypothesis, padj p value adjusted for multiple testing using Benjamini-Hochberg