Fig. 7

Active chromatin TADs/loops are more sensitive to 1,6 HD treatment. A Examples of stable/lost TAD boundaries. example “a, b” lost, example “c” stable. B Aggregation analysis of CTCF/SMC3 ChIP-seq peaks at stable/lost TAD boundaries. C Intra-/inter-TAD interaction changes (1,6-HD(+)/(−) ratio) in different subcompartments. Interactions between different subcompartments were skipped. D Examples of loop domain "b", and DNA stripe "a" after 1,6-HD treatment. E Schematic illustration of loop anchor interaction, loop domain, DNA stripe, and stripe anchor. F Left and right stripe signal aggregation at 10 kb resolution. G Aggregation analysis of loop domain (left) and loop anchor interaction (right) signal changes after 1,6-HD treatment. “both/no stripe” indicates both or no overlap between loop anchor and stripe anchor