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Fig. 6 | Genome Biology

Fig. 6

From: Quantifying the phase separation property of chromatin-associated proteins under physiological conditions using an anti-1,6-hexanediol index

Fig. 6

A/B compartment of chromatin exhibited different sensitivities to 1,6-HD treatment. A A (red) and B (blue) compartments can be classified into 4 compartment change-types as strengthened, stable, weakened based on their PC1 value ratio (1,6-HD+/−). 20% was chosen as the threshold for distinguishing stability or not. B The fraction of four kinds of compartment change-types. C Contact probability between compartments along genomic distance. D Examples of strengthened/stable compartments and corresponding nuclear speckle/lamina TSA-seq [39] plots. The plotting of log2 ratio of TSA read density versus input read density was used to measure the distance from a chromatin region to a specific nuclear condensate. Chr2, 0–80 M. E AICAP values of nuclear speckle and lamina associated proteins. Data resource [40, 41]

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Genome Biology

ISSN: 1474-760X

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