Fig. 6

Survival analysis showed the prognostic effect of MultiK derived reproducible T cell gene signatures compared to other T cell signatures as well as single gene expression (indicated on the Y-axis) in external breast cancer datasets. Forest plots show hazard ratio (circles) and 95% confidence intervals (horizontal ranges) derived from the Cox proportional hazards model for overall survival in univariate analysis. Red indicates significant hazard ratio estimate (p value < 0.05) whereas blue indicates non-significant estimate (p value ≥ 0.05). The first two vertical panels show results from combining all patients (first panel) and ER+HER2− patients (second panel) from the METABRIC, Harrell 855, TCGA BRCA, and SCAN-B datasets. The third vertical panel shows results from combining HER2+ patients from the Harrell 855, TCGA BRCA, SCAN-B, and CALGB40601 datasets. The fourth vertical panel shows results from combining TNBC patients from the METABRIC, Harrell 855, TCGA BRCA, and SCAN-B datasets