Fig. 5

MultiK identified robust and reproducible groups in the low-resolution space across six human T cell datasets via gene set enrichment analysis. a 2-d UMAP plot of the clusters at low-resolution (K = 13) in the Azizi et al. dataset. Each dot represents a single cell and each color presents a cluster. b Heatmap of reproducible T cell groups found in the other dataset using gene set enrichment analysis. Left is a dendrogram constructed from the 13 cluster means in the Azizi et al. dataset. Closed circles on the nodes indicate significant SigClust p values (< 0.05) suggesting a cluster is a class, whereas open circles on the nodes indicate non-significant SigClust p values (≥0.05) suggesting a cluster is a subclass. Right is a heatmap showing the presence (colored black) or absence (colored gray) of each Azizi et al. group in the other datasets. The reproducible groups are highlighted with asterisks at the end of each row in the heatmap