Fig. 4

MultiK identified robust and reproducible groups across five mouse mammary gland datasets via gene set enrichment analysis. Using the FVB3-mammary dataset as reference, gene set analysis across datasets in both low-resolution (a) and high-resolution (b) space after applying MultiK. In each panel, left is a dendrogram constructed from the cluster means in the FVB3-mammary dataset. Closed circles on the nodes indicate significant SigClust p values (< 0.05) suggesting a cluster is a class, whereas open circles on the nodes indicate non-significant SigClust p values (≥ 0.05) suggesting a cluster is a subclass. Right is a heatmap showing the presence (colored black) or absence (colored gray) of each FVB3-mammary group in the other datasets. The reproducible groups are highlighted with asterisks at the end of each row in the heatmap