Fig. 4
From: CoCoA-diff: counterfactual inference for single-cell gene expression analysis
Genes modulated by AD pathology highlight disease mechanisms in relevant cell types in gene ontology enrichment analysis. Ex, expiatory neurons; In, inhibitory neurons; Oligo, oligodendrocytes; OPC, oligodendrocyte progenitor cells; Mic, microglia; Astro, astrocytes. Each box is scaled proportional to the level of enrichment significance (p value), and the colour gradient marks the number genes overlapped in each keyword and cell type. a The number of significant genes modulated by AD pathology. b–d Top gene ontology terms in biological process over-represented by cell-type-specific AD genes. e Top gene ontology terms in cellular component over-represented by cell-type-specific AD genes. f Top gene ontology terms in molecular function over-represented by cell-type-specific AD genes