Fig. 1

Inferring differentiation trajectories at organismal scale. A Pijuan-Sala et al. [25] layout containing single-cell transcriptomes from E6.5 to E8.5, colored by sampled timepoint (left) and by cell-type (right). The overlaying arrows result from applying the scVelo pipeline to the whole embryonic dataset and represent inferred developmental trajectories. Arrowheads highlight the erythroid branch, displaying scVelo trajectory predictions that are inconsistent with real-time sampling. B Pijuan-Sala et al. [25] layout highlighting single-cell transcriptomes belonging to E7.5 (left) and E8.5 (right) and colored by cell-type (see legend in A). The overlaying arrows result from applying the scVelo pipeline to these individual timepoints and represent inferred developmental trajectories. Arrowheads highlight the erythroid branch