Table 1 Abbreviations used in the manuscript
From: Optimizing expression quantitative trait locus mapping workflows for single-cell studies
| Â | Definition |
|---|---|
eQTL | Expression quantitative trait locus/loci |
sc-eQTL | Single-cell eQTL |
eGene | Gene with at least one eQTL (at a given FDR threshold) |
LMM | Linear mixed model |
Matched datasets | (Bulk and single-cell) expression data from the same set of individuals with closely matched expression quantification. |
a-bulk | All bulk; eQTL results obtained using bulk RNA-seq data from all donors (n = 526) |
m-bulk | Matched bulk; eQTL results using bulk RNA-seq from matched donors (n = 87) |
SV | (Single-cell) sampling variation |
FDR | False discovery rate |
cFDR | Conditional FDR |
FWER | Family-wise error rate |
HVGs | Highly variable genes |
TMM | Trimmed mean of M-values; normalization method proposed in [1] |