Fig. 5

Conditional FDR increases eGene discovery in iPSC Smart-Seq2 data while replication fraction stays consistent. a Graphical summary of cFDR method. b The eGene discovery power using different FDR methods at an FDR of 5% for the respective method (p < 0.05 Bonferroni). Blue bars indicate eGenes that were replicated in all bulk (a-bulk) defined as FDR < 10% and the same direction of effect. Yellow bars indicate eGenes that were not replicated in bulk (number of total genes tested = 20,334). c The eGene discovery power using different external test statistics for cFDR. Tests were performed only on the subset of genes present in all four external datasets (GTEx metasoft RE2, FE, RE, and closest tissue) (13,653 genes tested). * denotes multiple testing correction methods that control the (much stricter) family-wise error rate