Fig. 5
From: Annotation of snoRNA abundance across human tissues reveals complex snoRNA-host gene relationships
Dual initiation of transcription uncouples the expression of the host and snoRNA genes and generates various RNA abundance patterns. A Most non- or anticorrelated snoRNA/HG pairs are expressed from promoters with dual-initiation sites. The density of snoRNA/HG pairs with dual-initiation (DI promoter) or simple-initiation (SI promoter) promoter is plotted as a factor of the correlation of abundance between snoRNA and their HG, for either UE or TE snoRNAs. The stars indicate the statistical significance of the difference between the DI and SI promoter groups (Mann-Whitney U test, ***p < 6 × 10− 4 and ***p < 2 × 10− 5, respectively for UE and TE snoRNAs). B TE snoRNAs are mostly expressed from genes with SI promoters. The proportion of snoRNAs with HGs displaying DI or SI promoters is represented in the form of a stacked bar chart, depending on their abundance class. The stars indicate the statistical significance of the difference between the two HG promoter types (Fisher’s exact test, ***p < 3 × 10− 8). C Most HGs displaying DI promoters are subject to NMD. The proportion of snoRNAs with a HG displaying a DI or a SI promoter, depending on if the HG is subject to NMD or not, was plotted as a stacked bar chart, for either UE or TE snoRNAs. The stars indicate the statistical significance of the difference between the two HG promoter types (Fisher’s exact test, ***p < 2 × 10− 14 and **p < 0.01, respectively for UE and TE snoRNAs). D Anti- or non-correlated TE snoRNAs embedded in a DI promoter HG are mainly expressed at high levels in female reproductive tissues. The HG name, the correlation of abundance, the tissue enrichment and the average abundance in the enriched tissue(s) of the seven non- or anticorrelated snoRNAs embedded in DI promoter HGs are indicated in a summary table