Fig. 3
From: Annotation of snoRNA abundance across human tissues reveals complex snoRNA-host gene relationships
The snoRNA abundance classes represent two groups with distinct characteristics, RNA levels and conservation patterns. A The TE and UE snoRNA abundances peak in different tissue types. The abundance of snoRNAs in each tissue per abundance class is represented in the form of a violin plot. B Box C/D snoRNAs form the majority of both abundance classes. The percentage of box C/D and H/ACA snoRNAs in each abundance class is shown in the form of a stacked bar chart. The stars indicate the statistical significance of the difference between the two classes of snoRNA abundance (Fisher’s exact test ***p < 0.001). C Most TE snoRNAs are orphans, whereas most UE snoRNAs target rRNA. The stacked bar charts indicate the distribution of the targets (either rRNA, snRNA or orphan, i.e., no known canonical target) of the different snoRNAs in each abundance class. The stars indicate the statistical significance of the difference between the two classes of snoRNA abundance (Fisher’s exact test ***p < 2 × 10− 14). D Most TE snoRNAs are embedded in the introns of non-coding HGs, whereas UE snoRNAs are mostly embedded in the introns of protein-coding HGs. The distribution of snoRNA HG biotype in each abundance class is shown as a stacked bar chart. The stars indicate the statistical significance of the difference between the two classes of snoRNA abundance (Fisher’s exact test ***p < 2 × 10− 10). E TE snoRNAs are less evolutionarily conserved than the UE class. The violin plots indicate the distribution of the phastCons conservation score in vertebrates for each abundance class. The stars indicate the statistical difference between the two distributions (Mann-Whitney U test, ***p < 8 × 10− 11)