Fig. 2

Deconvolution analysis identifies spatial-temporal change of cell-type composition during human heart development. a A schematic overview of the analysis. Spatial Transcriptomic data for developing heart were collected at three developmental stages by Asp et al. 2019. In parallel, single-cell RNAseq analysis was carried out to identify cell-type specific gene signatures. The spatialDWLS method was applied to infer the distribution of different cell-types across developmental stages. b The resulting estimates of the spatial distribution of different cell types. One representative sample was selected from each developmental stage. c A summary of the cell-type composition for all samples grouped by the corresponding developmental stages. d The assortativity analysis indicates an increased level of spatial clustering among similar cell types during heart development