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Table 1 Intersection of RepeatMasker defined reference genome (hg38) ERV sequences with ENCODE candidate cis-regulatory elements [2]. Values in brackets represent fold-change compared to random sampling, with bold font highlighting > 50% depletion (italicized) or enrichment (underlined). CTCF-bound elements have predicted insulator or looping function

From: Endogenous retroviruses in the origins and treatment of cancer

Family Reference genome (%) Promoter
(%, n = 60,338)
Proximal enhancer
(%, n = 141,830)
Distal enhancer
(%, n = 667,599)
CTCF-bound
(%, n = 56,766)
ERV 8.860 8.472 (1.0) 6.124 (0.7) 12.786 (1.4) 17.317 (2.0)
LTR5Hs (HERV-K) 0.019 0.008 (0.4) 0.032 (1.6) 0.037 (1.9) 0.014 (0.7)
LTR7 (HERV-H) 0.031 0.028 (0.9) 0.054 (1.7) 0.118 (3.9) 0.037 (1.2)
LTR17 (HERV-W) 0.016 0.017 (1.1) 0.008 (0.5) 0.012 (0.8) 0.012 (0.8)