Fig. 4

Impact of CTR region on FP rate and reproducibility. a FP rate in and outside of the CTR using two different methods (B_low and C_only) at three different VAF cutoffs, 1%, 2.5%, and 5%. C_only was not applied to TFS as sample C was not tested on TFS. FP rates are plotted in squared root scale. b Estimated FP rate within the CTR averaged over three methods at different VAF cutoffs. c Cross-lab reproducibility (in Phred scale) in samples A and C within and outside of the CTR