Fig. 3
From: Genetic variation and microRNA targeting of A-to-I RNA editing fine tune human tissue transcriptomes
Tissue-specific edQTL signals. a Example of a tissue-specific edQTL site with small effect size in skeletal muscle. Box plots show the association of rs1138054 with the editing level (Φ) at chr8:30535980 in GSR within the nucleus accumbens (left) and skeletal muscle (right). Each dot represents data from a particular individual. The dashed red line represents a linear fit of the data. b Low ADAR expression level in skeletal muscle correlates with small edQTL effect size. Bar plot (left) shows effect sizes of the association of rs1138054 with the editing level (Φ) at chr8:30535980 in GSR across 49 tissues. Box plot (right) shows ADAR expression level across 49 tissues, with outliers removed for clarity. Three tissues with smallest effect size and lowest ADAR expression level are highlighted. c Heatmap of edQTL effect sizes for 227 RNA editing sites (rows) across 49 tissues (columns). Only RNA editing sites with sufficient coverage to pass filters and have effect sizes computed across all 49 tissues are included in the plot. The RNA editing site in GSR as described in a and b is indicated with the arrow. d Heatmap of edQTL effect sizes for 77 RNA editing sites (rows) with large variation in edQTL effect sizes (|coefficient of variation| ≥ 1) across 49 tissues (columns). Only RNA editing sites with sufficient coverage to pass filters and have effect sizes computed across all 49 tissues are included in the plot. The RNA editing site in RABGEF1 as described in e and f is indicated with the arrow. e Example of a tissue-specific edQTL site with small effect size in whole blood. Box plots show the association of rs2707852 with the editing level (Φ) at chr7:66205046 in RABGEF1 within the tibial artery (left) and whole blood (right). Each dot represents data from a particular individual. The dashed red line represents a linear fit of the data. f Tissues with high ADARB1 expression level have a tissue-specific set of edQTL sites. Bar plot (left) shows effect sizes of the association of rs2707852 with the editing level (Φ) at chr7:66205046 in RABGEF1 across 49 tissues. Box plot (right) shows ADARB1 expression level across 49 tissues, with outliers removed for clarity. Tissues with largest effect size and highest ADARB1 expression level are highlighted