Fig. 4

Cell type-specific annotation of regulatory elements. a CellWalker maps putative regulatory elements (pREs) generated from microdissected brain regions to cell types using cell-to-label influence. b A significant fraction of inhibitory interneuron-specific pREs are closest to ASD-related genes (left) and a significant fraction of radial glia-specific pREs are closest to developmental delay-related genes (left). c Of the interneuron subtypes, newborn interneurons (nIN) and cortical interneurons (IN-CTX) are enriched for pREs near ASD genes, but there are only enough nIN-specific pREs to achieve statistical significance (left). Early radial glia (RG-early) are enriched for developmental delay genes (right). d The region surrounding an intronic SLC6A1 enhancer (yellow highlight). The enhancer is accessible throughout interneurons, but not in excitatory neurons (* represents significance at FDR < 0.1, ** at FDR < 0.05, and *** at FDR < 0.01)